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Do not use this medication if you are allergic to didanosine, or if you are also taking allopurinol (Zyloprim) or ribavirin (Rebetol, Ribasphere, Copegus Virazole). Unlike PURINETHOL (mercaptopurine) and IMURAN® (azathioprine), Thioguanine may be continued in the usual dosage when allopurinol is used conjointly to inhibit uric acid formation. In one study in mice, large amounts of allopurinol caused birth defects and other unwanted effects. Allopurinol will help prevent gout attacks only as long as you continue to take it. The total amount of allopurinol is usually not more than 800 mg a day.
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